Tiago G. Fernandes from SCERG-iBB is guest-editing a special topic for the open-access journal "Frontiers in Bioengineering and Biotechnology" entitled "Stem Cell Systems Bioengineering". Advances in the bioengineering field have allowed the manipulation of singular aspects of the cellular microenvironment, and this Research Topic aims to focus on outstanding examples of bioengineering approaches used to promote the self-organization of human cells and the production of tissue-like structure formation.