Case Report
Teratoma-negative anti-NMDA receptor encephalitis presenting with a single generalized tonic–clonic seizure

https://doi.org/10.1016/j.ebcr.2018.02.001Get rights and content
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Highlights

  • Teratoma-negative anti-NMDA receptor encephalitis presented with a single GTC seizure and prominent psychiatric symptoms.

  • We emphasize the importance of early treatment with immunotherapy in autoimmune epilepsy.

  • The literature on acute anti-NMDA receptor encephalitis presenting with one GTC seizure is reviewed.

Abstract

Herein, we describe a case report of anti-NMDA receptor encephalitis characterized by a single generalized tonic–clonic seizure and predominantly psychiatric symptoms, persisting long after EEG abnormalities had resolved. We discuss common presentations of anti-NMDA receptor encephalitis and advocate for the inclusion of this disease entity in the differential diagnosis of patients presenting with one generalized tonic–clonic seizure and prominent psychiatric symptoms.

Abbreviations

anti-NMDA
anti-N-methyl-d-aspartate
IVIg
Intravenous immunoglobulin
EEG
electroencephalogram
MRI
magnetic resonance imaging
PCR
polymerase chain reaction
HSV
herpes simplex virus
CSF
cerebral spinal fluid
CT
computerized tomography
F/U
follow up
GTC(S)
generalized tonic–clonic (seizure)

Keywords

Anti-NMDA encephalitis
Autoimmune
Seizure
Psychiatric symptoms

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