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Editorial commentary
Link between HLA alleles and anti-NMDAR encephalitis
  1. Noriko Isobe
  1. Department of Neurological Therapeutics, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
  1. Correspondence to Dr Noriko Isobe, Department of Neurological Therapeutics, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan; kuroki{at}neuro.med.kyushu-u.ac.jp

https://doi.org/10.1136/jnnp-2018-319925

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    HLA-DRB1*16:02 is a disease susceptibility allele for anti-NMDAR encephalitis in the Chinese Han population

    Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is one of the major types of antibody-mediated autoimmune encephalitis. It was originally reported to be highly prevalent in young women with ovarian teratoma, but later studies found that the cases were not limited to young women with tumours; it was observed in both genders of any age, irrespective of tumour positivity.1 Clinical manifestations include neuropsychiatric syndrome with movement disorders, seizures and autonomic dysfunction.

    Recently, several studies have reported human leucocyte antigen (HLA) associations with antibody-mediated encephalitis, including anti-NMDAR encephalitis and anti-leucine-rich glioma-inactivated1 (LGI1) encephalitis. While HLA-DRB1*07:01 or its extended …

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    Footnotes

    • Contributors Only NI is the author and no additional contributorship exists.

    • Funding This work was supported in part by a research grant from the Japan Intractable Disease Research Foundation and by a Grant-in-Aid for Scientific Research C (18K0752) from the Japan Society for the Promotion of Science, Japan.

    • Competing interests NI has received research support from Mitsubishi Tanabe Pharma, Osoegawa Neurology Clinic, and Japan Blood Products Organization, honoraria from Mitsubishi Tanabe Pharma and Alexion, and is a consultant for Oxford Health Policy Forum CIC.

    • Patient consent for publication Not required.

    • Provenance and peer review Commissioned; internally peer reviewed.

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    • Neurogenetics
      HLA class II allele DRB1*16:02 is associated with anti-NMDAR encephalitis
      Yaqing Shu Wei Qiu Junfeng Zheng Xiaobo Sun Junping Yin Xiaoli Yang Xiaoyang Yue Chen Chen Zhihui Deng Shasha Li Yu Yang Fuhua Peng Zhengqi Lu Xueqiang Hu Frank Petersen Xinhua Yu
      Journal of Neurology, Neurosurgery & Psychiatry 2019; 90 652-658 Published Online First: 13 Jan 2019. doi: 10.1136/jnnp-2018-319714