An anti-NMDA receptor encephalitis mimicking an HIV encephalitis

Fatiha Haneche; Sophie Demeret; Dimitri Psimaras; Christine Katlama; Valérie Pourcher

doi:10.1016/j.clim.2018.05.003

An anti-NMDA receptor encephalitis mimicking an HIV encephalitis

Clin Immunol. 2018 Aug:193:10-11. doi: 10.1016/j.clim.2018.05.003. Epub 2018 May 14.

Authors

Fatiha Haneche¹, Sophie Demeret², Dimitri Psimaras³, Christine Katlama⁴, Valérie Pourcher⁵

Affiliations

¹ Groupe Hospitalier Nord-Essonne, site Juvisy, 9 rue Camille Flammarion, 91260 Juvisy-sur-Orge, France. Electronic address: fatiha.haneche@aphp.fr.
² AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Département de neurologie, 47-83 Boulevard de l'hôpital, 75013 Paris, France. Electronic address: sophie.demeret@aphp.fr.
³ AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de neurologie 2-Mazarin, 47-83 boulevard de l'hôpital, 75013 Paris, France. Electronic address: dimitri.psimaras@aphp.fr.
⁴ AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Maladies Infectieuses et Tropicales, 47-83 boulevard de l'hôpital, 75013 Paris, France,; UPMC Sorbonne Universités, 4 Place Jussieu, 75005 Paris, France; INSERM, UMR S1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, 56 Boulevard Vincent-Auriol, 75646 Paris, France. Electronic address: christine.katlama@aphp.fr.
⁵ AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Maladies Infectieuses et Tropicales, 47-83 boulevard de l'hôpital, 75013 Paris, France,; UPMC Sorbonne Universités, 4 Place Jussieu, 75005 Paris, France; INSERM U1135 'HIV Pathogenesis and Immune Aging', Immunity and Infectious Diseases Research Center, 31, boulevard de l'hôpital, 75013 Paris, France. Electronic address: valerie.martinez@aphp.fr.

PMID: 29772276
DOI: 10.1016/j.clim.2018.05.003

Abstract

The incidence of HIV associated neurocognitive disorders (HAND) were reduced with the use of antiretroviral therapy. In case of neuropsychiatric symptoms, after elimination of all infections, auto-immune encephalitis could be evocated as a differential diagnosis. We describe a case of anti-N-Methyl-d-Aspartate receptor encephalitis in an HIV-1 infected woman.

Keywords: Anti-NMDA receptor antibodies; Autoimmune encephalitis; HIV.

Publication types

Case Reports
Letter

MeSH terms

Anti-N-Methyl-D-Aspartate Receptor Encephalitis / diagnosis
Anti-N-Methyl-D-Aspartate Receptor Encephalitis / drug therapy
Anti-N-Methyl-D-Aspartate Receptor Encephalitis / immunology*
Anxiety
Autoantibodies / cerebrospinal fluid*
Diagnosis, Differential
Electrocardiography
Female
HIV Infections / diagnosis
HIV Infections / drug therapy
HIV Infections / immunology*
HIV-1 / physiology*
Humans
Immunoglobulins, Intravenous / therapeutic use
Memory Disorders
Middle Aged
Receptors, N-Methyl-D-Aspartate / immunology*
Recovery of Function
Sleep Initiation and Maintenance Disorders

Substances

Autoantibodies
Immunoglobulins, Intravenous
Receptors, N-Methyl-D-Aspartate