Recurrent anti-NMDAR encephalitis during pregnancy combined with two antibodies positive

Hong Liu; Xiu Chen

doi:10.1007/s00737-021-01124-5

Recurrent anti-NMDAR encephalitis during pregnancy combined with two antibodies positive

Arch Womens Ment Health. 2021 Dec;24(6):1045-1050. doi: 10.1007/s00737-021-01124-5. Epub 2021 Apr 9.

Authors

Hong Liu¹, Xiu Chen²

Affiliations

¹ Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
² Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China. 706665270@qq.com.

Abstract

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune synaptic encephalitis likely mediated by neuronal surface antibody. Clinically, it is characterized by a variety of neurological and psychiatric symptoms, predominantly affecting young women. Recurrent anti-NMDAR cases combined with double-antibody positive during pregnancy have not been reported. We report a 19-year-old pregnant woman with recurrent anti-NMDAR encephalitis and double-antibody positive. Through our case report and a review of the literature, we hope to heighten an awareness of anti-NMDAR encephalitis, particularly in a pregnant setting.

Keywords: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis; Double-antibody positive; Pregnancy; Recurrent.

Publication types

Case Reports
Research Support, Non-U.S. Gov't
Review

MeSH terms

Adult
Anti-N-Methyl-D-Aspartate Receptor Encephalitis* / diagnosis
Autoantibodies
Female
Hashimoto Disease*
Humans
Pregnancy
Young Adult

Substances

Autoantibodies